Vitamin B1 Analogue Benfotiamine Prevents Diabetes-Induced Diastolic Dysfunction and Heart Failure through Akt/Pim-1 Mediated Survival Pathway Katare et al. Benfotiamine prevents diabetic cardiomyopathy
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Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response.
Benfotiamine (BFT) is a transketolase activator that directs glucose to the pentose phosphate pathway. The present study investigated whether BFT improves the recovery after myocardial infarction (MI) and explored underlying mechanisms of protection. Non-diabetic and streptozotocin-induced type 1 diabetic mice were supplemented with BFT (70 mg/kg/day in drinking water) for 4 weeks and then subj...
متن کاملBenfotiamine and Type 2 Diabetes Mellitus
The number of people with type 2 diabetes mellitus (T2DM) has been increasing worldwide [1]. The majority of patients with long-term course of diabetes mellitus (DM) (mainly T2DM) are diagnosed with cardiovascular diseases. Conditionally, there are two main forms of heart disease in case of DM: diabetic cardiomyopathy and ischemic heart disease (IHD). There is a metabolic stage (actual cardiomy...
متن کاملBenfotiamine and Type 2 Diabetes Mellitus
The number of people with type 2 diabetes mellitus (T2DM) has been increasing worldwide [1]. The majority of patients with long-term course of diabetes mellitus (DM) (mainly T2DM) are diagnosed with cardiovascular diseases. Conditionally, there are two main forms of heart disease in case of DM: diabetic cardiomyopathy and ischemic heart disease (IHD). There is a metabolic stage (actual cardiomy...
متن کاملRapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1
BACKGROUND Diabetic women are five times more likely to develop congestive heart failure compared with two fold for men. The underlying mechanism for this gender difference is not known. Here we investigate the molecular mechanisms responsible for this female disadvantage and attempt safeguarding cardiomyocytes viability and function through restoration of pro-survival Pim-1. METHODS AND RESU...
متن کاملBenfotiamine Monograph
Introduction Neurological disorders, particularly diabetic neuropathy, have been treated with vitamin B1 (thiamine) for decades; however, the bioavailability of orally administered, water-soluble thiamine salts is low compared to fat-soluble analogs. For treatment to be successful, high levels of thiamine are needed in both blood and tissues. In 1954, Fujiwara discovered a group of lipid-solubl...
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تاریخ انتشار 2010